- Review Article
- General Pediatrics
- The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
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Jae Hyun Kim, Sungha Yun, Seung-sik Hwang, Jung Ok Shim, Hyun Wook Chae, Yeoun Joo Lee, Ji Hyuk Lee, Soon Chul Kim, Dohee Lim, Sei Won Yang, Kyungwon Oh, Jin Soo Moon; for the Committee for the Development of Growth Standards for Korean Children and Adolescents, the Committee for School Health and Public Health Statistics; the Committee for School Health and Public Health Statistics; the Korean Pediatric Society, and Division of Health and Nutrition Survey; Korea Centers for Disease Control and Prevention
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Clin Exp Pediatr. 2018;61(5):135-149. Published online May 28, 2018
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Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index... |
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- Original Article
- Neonatology (Perinatology)
- Healthcare access challenges facing six African refugee mothers in South Korea: a qualitative multiple-case study
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Min Sun Kim, In Gyu Song, Ah Reum An, Kyae Hyung Kim, Ji Hoon Sohn, Sei Won Yang
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Clin Exp Pediatr. 2017;60(5):138-144. Published online May 31, 2017
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Purpose Following legal reform in 2013, the annual number of asylum seekers entering South Korea has increased from 1,143 in 2012 to 5,711 in 2015. We interviewed six African refugee mothers of young children regarding their health needs and barriers to access maternal child health services. MethodsWe recruited mothers who had visited a clinic for immigrants between July 2013 and August 2015.... |
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- Case Report
- Autosomal dominant hypocalcemia with Bartter syndrome due to a novel activating mutation of calcium sensing receptor, Y829C
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Keun Hee Choi, Choong Ho Shin, Sei Won Yang, Hae Il Cheong
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Clin Exp Pediatr. 2015;58(4):148-153. Published online April 22, 2015
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The calcium sensing receptor (CaSR) plays an important role in calcium homeostasis. Activating mutations of CaSR cause autosomal dominant hypocalcemia by affecting parathyroid hormone secretion in parathyroid gland and calcium resorption in kidney. They can also cause a type 5 Bartter syndrome by inhibiting the apical potassium channel in the thick ascending limb of the loop of Henle in the... |
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- Original Article
- Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
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Sung Yeon Ahn, Sei Won Yang, Hee Jae Lee, Jong Seon Byun, Ji Yeon Om, Choong Ho Shin
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Clin Exp Pediatr. 2012;55(9):337-343. Published online September 14, 2012
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Purpose Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty. MethodsLeptin (1 µg) was injected directly into... |
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- Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity
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Jieun Lee, Juyoung Yoon, Jin A Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2012;55(9):344-349. Published online September 14, 2012
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Purpose Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism. MethodsA total of 79 girls (6.3 to 12.4 years) were included in... |
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- Risk factor for pituitary dysfunction in children and adolescents with Rathke's cleft cysts
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Han Hyuk Lim, Sei Won Yang
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Clin Exp Pediatr. 2010;53(7):759-765. Published online July 31, 2010
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Purpose This study evaluated the clinical manifestations of and risk factors for pituitary insufficiency in children and adolescents with Rathke's cleft cysts. MethodsForty-four patients with Rathke's cleft cysts younger than 19 years who visited Seoul National University Children's Hospital between January 1995 and September 2009 were enrolled. Rathke's cleft cysts were confirmed histologically through an operation in 15 patients and by brain... |
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- Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency
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Han Hyuk Lim, Min Jae Kang, In Suk Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2010;53(10):892-897. Published online October 31, 2010
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Purpose This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD). MethodsThirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference,... |
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- Remission rate and remission predictors of Graves disease in children and adolescents
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Sun Hee Lee, Seong Yong Lee, Hye Rim Chung, Jae Hyun Kim, Ji Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin
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Clin Exp Pediatr. 2009;52(9):1021-1028. Published online September 15, 2009
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Purpose : Medical therapy is the initial treatment for children with Graves disease to avoid complications of other treatments. However, optimal treatment for childhood Graves disease is controversial because most patients require relatively long periods of medical therapy and relapse is common after medication discontinuation. Therefore, this study aimed to search clinical or biochemical characteristics that could be used as... |
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- Growth responses to growth hormone therapy in children with attenuated growth
who showed normal growth hormone response to stimulation tests
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Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(8):922-929. Published online August 15, 2009
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Purpose:The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children
with attenuated growth who showed normal GH responses to GH stimulation tests (GHST).
Methods:The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical
characteristics of patients were analyzed retrospectively.
Results:Eleven were born as small for gestational age (SGA)... |
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- Development of metabolic syndrome and its correlation with insulin resistance in adult patients with Turner syndrome
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Joo Hwa Kim, Min Jae Kang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(3):370-375. Published online March 15, 2009
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Purpose : The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance.
Methods : Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin... |
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- Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
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Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(2):227-233. Published online February 15, 2009
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Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD.
Methods :... |
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- Case Report
- A case of testicular adrenal rest tumor in a
male child with congenital adrenal hyperplasia
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Joo Hwa Kim, Kyong Ah Yun, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2008;51(9):1018-1022. Published online September 15, 2008
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Testicular adrenal rest tumors are a well-known complication in male patients with congenital adrenal hyperplasia. Corticosteroid suppressive therapy usually results in the regression of these tumors. We describe a patient with 21-hydroxylase deficiency who developed bilateral testicular masses. Despite steroid suppressive therapy, the tumors did not regress and hormonal control was poor. Consequently, bilateral partial orchiectomies were performed. |
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- Original Article
- Interpretation of screening for congenital adrenal hyperplasia in preterm infants
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Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Kyong Ah Yun, Young Ah Lee, So Eun Park, Chang Won Choi, Byung Il Kim, Jung Hwan Choi, Junghan Song
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Clin Exp Pediatr. 2008;51(6):616-621. Published online June 15, 2008
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Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants.
Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone... |
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- Case Report
- Pheochromocytoma associated with
cyanotic congenital heart disease
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Seung Joon Chung, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Eun Jung Bae, Jung Il Noh
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Clin Exp Pediatr. 2008;51(1):93-97. Published online January 15, 2008
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Pheochromocytoma is a rare tumor of childhood, arising from adrenal medullary and chromaffin tissue. Because chronic hypoxia may induce pheochromocytoma, there have been several reports of pheochromocytoma development in cyanotic patients after corrective or palliative cardiac surgery. The variable clinical presentation of pheochromocytoma is obscured by both underlying heart disease and medications. If sudden hypertension, aggravation of a heart condition,... |
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- Original Article
- A study and the growth and the development of microvascular complications in patients with type 1 diabetes mellitus
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Young Ah Lee, Kyong-Ah Yun, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2007;50(2):190-197. Published online February 15, 2007
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Purpose : Reduced growth and microvascular complications have been recognized as consequences of type 1 diabetes mellitus (T1DM). We assessed the effect of T1DM on growth and factors associated with the development of microvascular complications.
Methods : We conducted a retrospective longitudinal evaluation of 154 patients above 16 years of age. We analyzed factors which affect final height standard deviation scores... |
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- Clinical, endocrinological and radiological courses in patients who
was initially diagnosed as idiopathic central diabetes insipidus
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Seung Joon Chung, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2007;50(11):1110-1115. Published online November 15, 2007
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Purpose : Idiopathic central diabetes insipidus (CDI) is defined in CDI patients without definite etiology. Some patients initially diagnosed as idiopathic CDI progressed to organic causes. We reviewed clinical, endocrinological, and radiological courses of 20 patients who was initially diagnosed as idiopathic CDI, to assess the predicting factors for progression to brain tumors.
Methods : We reviewed the medical data and... |
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- Factors affecting the final adult height in survivors of childhood brain tumors
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Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
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Clin Exp Pediatr. 2007;50(1):65-73. Published online January 15, 2007
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Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature.
Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to... |
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- Case Report
- A case of Rothmund-Thomson syndrome
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Seung Hyo Kim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2006;49(5):565-569. Published online May 15, 2006
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Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by : skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities include : dysplasia, absent or malformed bones, such as absent radii, osteopenia, and delayed bone formation. RTS is thought to result from chromosomal instability, and children with RTS... |
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- Original Article
- Endocrine dysfunction and growth in children with medulloblastoma
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In Suk Yoon, Ji Young Seo, Choong Ho Shin, Il Han Kim, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2006;49(3):292-297. Published online March 15, 2006
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Purpose : In medulloblastoma, craniospinal radiation therapy combined with chemotherapy improves the prognosis of tumors but results in significant endocrine morbidities. We studied the endocrine morbidity, especially growth pattern changes.
Methods : The medical records of 37 patients with medulloblastoma were reviewed retrospectively for evaluation of endocrine function and growth. We performed the growth hormone stimulation test in 16 patients whose... |
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- Human Leukocyte Antigen(HLA) Genotypes and Thyroid Autoimmunity in Korean Patients with Type 1 Diabetes
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So Young Kang, Chung Ho Shin, Sei Won Yang, Myoung Hee Park, Jeesuk Yu
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Clin Exp Pediatr. 2005;48(6):624-633. Published online June 15, 2005
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Purpose : This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders.
Methods : A total of 59 Korean patients with type... |
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- Clinical Characteristics of Autoimmune Thyroid Disease Developed in Patients with Type 1 Diabetes Mellitus
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Se Min Lee, Hye Rim Chung, Su Young Hong, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(3):292-297. Published online March 15, 2005
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Purpose : It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean.
Methods : The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004,... |
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- Case Report
- Hyperthyroidism Caused by a Mutation in the Thyrotropin Receptor Gene in Two Brothers
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Jae Hyun Kim, Sung Soo Lee, Jung Sub Lim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(3):337-341. Published online March 15, 2005
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Thyrotropin receptor(TSHR) mutations must be considered when congenital hyperthyroidism has persisted, but there has been no evidence for autoimmunity. TSHR mutations leading to constitutive activation of the thyroid gland were identified as the molecular cause of autosomal dominant nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism. We report two cases of hyperthyroidism caused by germline TSHR mutation who presented with exessive sweating... |
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- Original Article
- Factors Affecting Final Adult Height in Patients with Turner Syndrome
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Jae Hyun Kim, Sung Soo Lee, Su Young Hong, Hye Rim Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(2):191-196. Published online February 15, 2005
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Purpose : Short stature is one of the characteristic features of Turner syndrome. We investigated the factors affecting final adult height(FAH) in patients with Turner syndrome.
Methods : The study group was comprised of 60 patients who were diagnosed with Turner syndrome by chromosomal study and clinical phenotypes and attained FAH. Data were obtained from retrospective review of the medical records.... |
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- Factors Affecting the Increments of Body Mass Index in Adult Survivors of Childhood Brain Tumors
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Jae Ho Yoo, Sung Yeon Ahn, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(9):970-977. Published online September 15, 2004
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Purpose : The purpose of this study was to evaluate the factors affecting the increments of body mass index(BMI) in adult survivors from childhood brain tumors.
Methods : We retrospectively reviewed medical records of 63 patients who were diagnosed with brain tumors and treated at Seoul National University Children's Hospital between 1982 and 2000. We evaluated the factors affecting adult BMI(aBMI)... |
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- Alteration of Bone Metabolism Markers According to the Progression of Puberty
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Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(2):140-149. Published online February 15, 2004
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Purpose : The object of this study is to evaluate bone metabolism in healthy adolescents according to the progression of puberty.
Methods : Forty boys(13.9?.7 years) and 42 girls(12.1?.6 years) were classified by Tanner stage (TS) and bone age. Serum levels of osteocalcin(OC) and bone specific alkaline phosphatase(BALP) were measured as bone formation markers. Serum level of C-terminal telopeptide of type... |
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- Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children
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Hye Rim Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(1):76-80. Published online January 15, 2004
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Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children.
Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,... |
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- The Separate and Combined Effects of Insulin, Dexamethasone and
Growth Hormone on the OB Gene Expression and Leptin Secretion
from Cultured Human Visceral Adipose Tissue
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Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(8):795-802. Published online August 15, 2003
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Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue.
Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin＋DEX(100 nM each), insulin＋DEX＋GH(100 nM insulin... |
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- Endocrine Function and Growth in Children with Craniopharyngioma
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Yoo Mi Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(3):277-283. Published online March 15, 2003
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Purpose : Craniopharyngiomas are often accompanied by severe endocrine disorders. Although there is universal growth hormone deficiency(GHD), the resulting growth pattern is very heterogeneous. We report the growth and endocrine outcome of 44 children with craniopharyngioma, with emphasis on initial symptoms, growth before and during growth hormone(GH) treatment and spontaneous growth in spite of GHD.
Methods : We performed a... |
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- Changes of Bone Metabolism Markers and Bone Mineral
Density with Improvement of Thyroid Function in
Children and Adolescents with Hyperthyroidism
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Min Ho Jung, Choong Ho Shin, Sei Won Yang, Byung Churl Lee
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Clin Exp Pediatr. 2002;45(6):743-753. Published online June 15, 2002
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Purpose : Dynamics of bone mineral density(BMD) and bone metabolism in children and adolescents with hyperthyroidism have not been thoroughly investigated. The aim of this study was to study how the improvement of thyroid function with antithyroid treatment influenced bone metabolism and BMD in children and adolescents with hyperthyroidism.
Methods : Serum levels of osteocalcin(OC), bone-specific alkaline phosphatase(b-ALP), and carboxyterminal telopeptide... |
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- Clinical Characteristics of Type 2 Diabetes in
Children and Adolescents
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Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2002;45(6):754-763. Published online June 15, 2002
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Purpose : The incidence of type 2 diabetes in children and adolescents has been reported to increase recently. The aim of this study is to investigate the clinical features of type 2 diabetes developing during childhood and adolescent period.
Methods : The medical records of 33 patients with type 2 diabetes were reviewed. We analysed clinical manifestations, demographic data, and modes... |
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- Effects of Insulin Level on Dyslipidemia in
Children with Simple Obesity
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Jung Sub Lim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2002;45(6):764-772. Published online June 15, 2002
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Purpose : Obesity is closely related to insulin resistance, compensatory hyperinsulinemia and dyslipidemia in adults. We identified the effect of obesity measured by BMI and insulin resistance on dyslipidemia in children and adolescents.
Methods : The fasting serum insulin, glucose, total cholesterol, triglyceride, HDL- and LDL-cholesterol were measured and insulin resistance(HOMA-IR) was calculated in 35 children with simple obesity(age :... |
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- Case Report
- A Case of Citrullinemia Diagnosed at the Neonatal Period
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Seung Kyu Song, Kyung Chang Oh, Mi Ae Hong, Hee Taeg Kim, Hye Jung Shin, Soon Young Kim, Jin Keun Chang, Heui Seung Jo, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi
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Clin Exp Pediatr. 2002;45(4):524-528. Published online April 15, 2002
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Citrullinemia is a rare inborn error of metabolism of the urea cycle, and was first reported by McMurray, et al. in 1962. It is inherited as an autosomal recessive trait. The normal synthesis of argininosuccinic acid is blocked in this disease due to a deficiency of argininosuccinic acid synthetase(AS), which has been demonstrated in liver cells and fibroblasts. The clinical... |
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- Factors Related to the Development of Microalbuminuria in
Children and Adolescents with Type 1 Diabetes Mellitus
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Min Ho Jung, Pei Tai Wan, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2001;44(5):577-586. Published online May 15, 2001
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Purpose : We observed the prevalence rate of microalbuminuria(MA) and its relationship with the various clinical factors in children and adolescents with type 1 diabetes mellitus(DM).
Methods : Seventy two children and adolescents(26 males and 46 females, 17.1±3.0 years) were included. MA was defined as 24 hour urine microalbumin >30mg/day(20μg/min). Subjects were classified into three groups(normoalbuminuria, transient MA, or persistent MA).... |
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- Clinical Characteristics of Williams Syndrome
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Choong Ho Shin, Ho Sung Kim, Sei Won Yang, Jung Yun Choi
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Clin Exp Pediatr. 2001;44(4):443-449. Published online April 15, 2001
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Purpose : Williams syndrome(WS) is an autosomal dominant disorder resulting from a submicroscopic deletion of contiguous genes on the long arm of chromosome 7. We evaluated the physical, neurodevelopmental, and behavioral characteristics of children and adults with WS confirmed by fluorescence in situ hybridization.
Methods : The clinically suspicious twelve cases with cardiac anomaly were confirmed as WS with fluorescence in... |
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- Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus
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Jin Soon Hwang, Sei Won Yang
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Clin Exp Pediatr. 2000;43(8):1106-1110. Published online August 15, 2000
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Purpose : Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic β-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic β-cell function. The aim of this study was to determine factors influencing the onset of honeymoon period in children with type... |
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- Case Report
- A Case of Hepatoblastoma with Precocious Puberty
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Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2000;43(2):288-293. Published online February 15, 2000
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Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,... |
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- Original Article
- Role of Polymorphism in HLA DQ-α and -β Chain Loci in the Pathophysiology of Autoimmune Thyroid Disease in Children with and without Turner Syndrome
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Kye Shik Shim, Kyu Chul Choeh, Sei Won Yang, Sa Jun Chung, Jin Sung Lee, Kyung Tae Lee, Sung Ho Goh, Yong Sung Kim
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Clin Exp Pediatr. 1999;42(7):980-990. Published online July 15, 1999
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Purpose : About 10% of girls with Turner syndrome may have autoimmune thyroid disease(AIT), but the disease's pathophysiology has not yet been elucidated. Accordingly, this study was performed to observe whether the pathogenesis of AIT in children with Turner syndrome and without Turner syndrome correlate with special loci of DQ α and β chain in HLA.
Methods : Blood samples were... |
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- Renal Problems in Wilson Disease
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Il Soo Ha, Jun Ho Lee, Yeon Ho Choe, Hae Il Cheong, Sei Won Yang, Young Yull Koh, Jeong Kee Seo, Yong Choi
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Clin Exp Pediatr. 1999;42(6):817-824. Published online June 15, 1999
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Purpose : Wilson disease is a hereditary metabolic disorder characterized by an accumulation of copper in tissues which sometimes results in renal problems. This study was performed to evaluate the prevalences of the renal problems in Wilson disease and related risk factors.
Methods : In 31 patients with Wilson disease, we looked for renal problems by history taking, physical examination... |
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- Re-Evaluation of Neonatal Screening Tests for Inborn Errors of
Metabolism with Dried Filter Paper Blood Spots
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Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
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Clin Exp Pediatr. 1999;42(12):1639-1644. Published online December 15, 1999
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Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates.
Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases... |
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- Clinical Lecture
- Failure to Thrive
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Sei Won Yang
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Clin Exp Pediatr. 1998;41(2):147-153. Published online February 15, 1998
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- Original Article
- The Effect of Recombinant Human Growth Hormone on the Growth in the Children with Chronic Renal Failure
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Sei Won Yang, Young Choi
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Clin Exp Pediatr. 1996;39(7):997-1004. Published online July 15, 1996
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Purpose : We observed the effect of three year-administration of recombinant human growth
hormone(rhGH) on the growth in the children with chronic renal failure(CRF).
Methods : Five prepubertal children(three boys and two girls) with CRF, who had been
managed by conservative methods, were given rhGH(1 U/kg/week) for three years. Growth
parameters, such as growth velocity, height standard deviation score(SDS), and predicted final
adult height, obtained... |
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- Case Report
- A Case of Mauriac's syndrome
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Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
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Clin Exp Pediatr. 1996;39(7):1020-1024. Published online July 15, 1996
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Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin
dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide
availability of insulin and intensification of diabetic control, this entity has become quite rare. A
9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia,
short stature, and visual disturbance. Five years prior to admission, she... |
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- Original Article
- The Changes of the Bone Mineral Density in the Girls with Turner Syndrome, using Recombinant Human Growth Hormone
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Sei Won Yang
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Clin Exp Pediatr. 1996;39(6):839-845. Published online June 15, 1996
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Purpose : Estrogen deficiency causes sexual infantilism in Turner syndrome, which
could decrease the bone mineral density(BMD) since birth. This decreased BMD might
be contributed by the decreased growth hormone(GH) secretion. To improve the decreased BMD, estrogen therapy is recommended, especially after the pubertal age, but estrogen therpay during childhood can accelerate the epiphyseal fusion, resulting in shorter final height. There is... |
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- Case Report
- A Pediatric Case of MELAS Syndrome Associated with Insulin-dependent Diabetes Mellitus
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Kyung Ran Park, Hye Won Park, Tae Sung Ko, Hae Il Cheong, Sei Won Yang, Young Seung Hwang, In Won Kim, Je Geun Chi
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Clin Exp Pediatr. 1996;39(10):1461-1465. Published online October 15, 1996
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MELAS(mitochondrial myopathy, encephalopathy, lactic acidosis, and sroke like episodes) is a
major subgroup of heterogeneous mitochondrial encephalopathy. Recent advances in molecular
genetics revealed specific mutations in the mitochondrial DNA causing MELAS. We described
clinical and molecular genetic findings of a 13-year-old boy with MELAS syndrome associated
IDDM(insulin dependent diabetes mellitus). For molecular genetic studies, DNAs from peripheral
blood nucleated cells were used. And the A→G... |
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- Original Article
- Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
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Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
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Clin Exp Pediatr. 1996;39(1):106-114. Published online January 15, 1996
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Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy.
Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid
mothers and their babies between 1988 and 1994.
Results :... |
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- Upper Limit of Normal Value for Antistreptolysin O Titer of Healthy Children in Seoul
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Sung Ho Cha, Yong Mook Choi, Sei Won Yang, Dong Hwan Lee, Chong Guk Lee, Chang Ho Hong
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Clin Exp Pediatr. 1995;38(8):1061-1068. Published online August 15, 1995
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Purpose : We have found somewhat high titer of antistreptolysin O (ASO) accidentally when we had delineated normal carrier rate of beta hemolytic streptococci in rural area of Kangwon Province in 1991(1). We would like to know upper limit of normal value of ASO and re-valuated results which might be changed with different geographic areas, age, and prevalent rate... |
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- Case Report
- Two Cases of Tetrahydrobiopterin Deficiency
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Jee Won Choi, Sei Won Yang, Hyung Ro Moon, Se Chin Cho
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Clin Exp Pediatr. 1995;38(3):397-403. Published online March 15, 1995
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Tetrahydrobiopterin(BH4) deficiency is a rare type of hyperphenylalaninemia and usually leads to a progressive neurologic deterioration despite early dietary control of blood phenylalanine concentration.
We experienced two cases of BH4 deficiency in brother and sister, confirmed by biochemical study of blood and urine. They had suffered from a progressive neurologic illness such as mental retardation, severe hypotonia, seizure, and athetotic movements... |
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- Original Article
- Cushing Syndrome in Children and Adolescents
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Choong Ho Shin, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1995;38(12):1677-1685. Published online December 15, 1995
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Purpose : Cushing syndrome occurs rarely in children and adolescents. The clinical manifestation is variable and growth is usually adversely affected.
Methods : We retrospectively analyzed 8 patients with Cushing syndrome between the ages of 1 and 14 year who were admitted to the pediatric department of Seoul National University Children's Hospital during the period from 1978 to 1995.
Results : 1)... |
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- The Growth Hormone Response to Growth Hormone-Releasing Hexapeptide (GHRP-6) in the Sprague Dawley Rat with Hypothyroidism
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Sei Won Yang
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Clin Exp Pediatr. 1994;37(1):89-98. Published online January 15, 1994
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We studied the effects of growth hormone to subthreshold, threshold, or suprathershold dose of growth hormone-releasing hexapeptide (GHRP-6) in conscious and unconscious (anesthesized with ketamine and phenobarbital) female Sprague Dawley rats with hypothyroidism, induced with methimazole and compared these results with those in conscious and unconscious rats with euthyroidism.
The results were as below;
1) In conscious rats, the peak GH response... |
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- Re-evaluation of TSH Screening TEST in Neonates
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Jin Young Song, Dong Woo Son, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi, Chong Ku Yoon, Hyung Ro Moon
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Clin Exp Pediatr. 1993;36(11):1502-1506. Published online November 15, 1993
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Five years ago, we made the cut-off value of TSH by dry filter paper method as 15μU/ml to screening congenital hypothyrodism. Since then, 1,210 term neonates, who had no perinatal problems, screening test with this cut-off point. Neonates had been recalled for measurement of serum T4/TSH to rule out congenital hypothyroidism if their TSH value by screening tests reveal more... |
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- Original Article
- The etiologies and the clinical manifestations of hypoglycemia in infancy and childhood.
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Nam Seon Beck, Dong Joo Shin, Heon Seok Han, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1991;34(4):480-486. Published online April 30, 1991
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To analysis age at onset, clinical manifestations, etiologies, complication and management of
hypoglycemia, the authors reviewed seventeen cases of hypoglycemia who were admitted to Seoul
National University Children’s Hospital because of hypoglycemic symtoms from March, 1982 to
February, 1990. In neonate group, which included five patients, their initial symtoms were apnea,
cyanosis, sweating and hand rigidity, with the causes of two hyperinsulinemic hypoglycemias, one... |
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- Pituitary Function on Patients with Sellar and Suprasellar Tumor.
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Sei Won Yang, Hyung Ro Moon, Byung Kyu Cho
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Clin Exp Pediatr. 1990;33(4):491-498. Published online April 30, 1990
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We observed the status of pituitary hormones (growth hormone, TSH, ACTH, gonadotropin and
ADH) in the patients with intrasellar and suprasellar tumors (Table 1 and 2) before and after
treatment of tumors. They were estimated from the results of various provocative tests to the
pituitary hormones after confimation of normal thyroid function.
The results were as belows (Table 3 and 4):
1) Most patients with craniopharyngioma... |
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- Bone Age Determination and Hand Radiographic Findings in Children With Russell-Silver Syndrome.
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Hun Kyu Lim, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1989;32(6):823-833. Published online June 30, 1989
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Russell.Silver syndrome is a disease of unknown etiology characterized by prenatal onset dwarfism
irrespective of full term gestation, growth retardation, body asymmetry, craniofacial dysproportion
with a triangular face, short and incurved little finger, etc.
Forty.two children were diagnosed as Russell.Silver syndrome by Silver’s criteria at SNU Children'
s Hospital from Apr. 1981 till Aug. 1988, and we reviewed clinical data and hand radiographs of... |
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- A Case of Mixed Gonadal Dysgenesis.
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Byung Ran Yun, Jae Il Sohn, Sei Won Yang, Hyung Ro Moon, Je Geun Chi
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Clin Exp Pediatr. 1989;32(12):1757-1762. Published online December 31, 1989
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Mixed gonadal dysenesis is a disorder of sexual differentiation which is characterized by streak
gonad associated with contralateral tesis, persistent Mullerian duct structures and/or sex
chromosomal mosaicism most commonly with 45, X/46, XY.
The authors experienced a case of mixed gonadal dysgensis in a 6-year old child who was reared
as female and admitted due to clitoral enlargement.
The patient had asymmetrical gonads consisted with... |
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- Study on the Clitoral Size of the Korean Female Newborn.
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Jong Lin Rhi, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1988;31(8):1007-1013. Published online August 31, 1988
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The disturbance of sex hormone secretions during the fetal life results in abnormal development of
the fetal sex organs including the external genitalia. In the congenital adrenal hyperplasia, especially,
the external genitalia is often virilized at birth and the clitomegaly in this disorder can be an important
clue for the early diagnosis.
For the normal range of the clitoral size of the Korean female... |
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- Comparison of the Effects of Portacaval Shunt and Dietary therapy in Type I Gyocogen Storagy Diseases(GSD).
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Dong Hyun Ju, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1988;31(6):762-771. Published online June 30, 1988
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Type I GSD is a metabolic disease resulted from defective glucose-6-phosphatase activities in liver,
kindey and intestine. They are characterized by growth retardation, enlargement of liver and kidney,
hypoglycemia, hyperuricemia, and hyperlipidemia.
Various methods were suggested for the management of GSD. They are night-time nasogastric
feeding of glucose solution with frequent day-time feeding, intravenous hyperalimentation, cornstarch
therapy end-to-side portacaval shunt, etc.
In this study, the effects... |
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- Normal TSH Levels in Neonates by TSH Screening test.
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Jae Won Song, Jong Lin Rhi, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Hyung Ro Moon, Bo Youn Cho, Chang Soon Koh
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Clin Exp Pediatr. 1988;31(6):754-761. Published online June 30, 1988
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In 110 term neonates without perinatal problems who were bom in SNUH, blood TSH levels were
measured by TSH screening test for congenital hypothyroidism. The results are as follows
1) Normal TSH level was 14.8±7.8 µU/ml, 8.8±4.7 µU/ml, and 6.5±2.7 µU/ml in neonates of age
0 〜24 hours, 24—48 hours, and 48〜72 hours respectively, and all TSH values in neonates of age
48〜72 hours were... |
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- A Case of Familial Dysautonomia.
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Hong Jin Lee, Dong Kyu Jin, Sei Won Yang, Jeong Kee Seo, Hyung Ro Moon, Je Geun Chi
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Clin Exp Pediatr. 1988;31(5):648-654. Published online May 31, 1988
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Few documented cases of Familial dysautonomia fulfilling current diagnostic criteria have been
recognized in non-Jews especially in orientals. In our case diagnosis was established in 8 year old
Korean girl. She fulfilled 8 out of 9 essential diagnostic criteria of Riley. It represents a report of
this syndrome with achalasia and improved with modified Heller’s myotomy. |
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- The Prevalence of Antithyroid Autoantibodies in Korean Children.
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Bung Hai Ahn, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1988;31(3):329-338. Published online March 31, 1988
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The prevalence of antithyroid autoantibodies and the relationship between the presence of
autoantibodies and thyroid functions were studied in 752 Korean children of 10 to 15 years of age with
normal thyroids. Antimicrosomal antibodies (AMA) were measured by the indirect agglutination
technique using artificial gelatin particle carriers sensitized with thyroid microsomal antigen and
antithyroglobulin antibodies (ATA) by the tanned red cell hemagglutination technique.
Circulating AMA... |
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- Russell-Silver Syndrome.
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Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1986;29(7):715-722. Published online July 31, 1986
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Seventeen cases(12 boys and 4 girls) with Russell-Silver syndrome were evaluated for weight,
height and bone age at initial presentation and during follow up.
1) Distribution of patient` s age at initial presentation was between 1 day and 75/12 year of age.
2) In 14 cases, the birth weight was below 3 percentile except for one case(3 percentile). In 15 cases,
the... |
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- Congenital adrenal Hyperplasia.
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Byoung Hai Ahn, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1986;29(6):604-612. Published online June 30, 1986
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Clinical data of twenty-eight children with congenital adrenal hyperplasia who were admitted to the Seoul National University Hospital from June 1979 to July 1984 were analyzed retrospectively. Male to female ratio was 1 : 1.3. The average age at diagnosis was 3.2 years, 1.3 months for eleven salt-losers and all were 3 months or younger, 4.6 years for seventeen nonsaltlosers.... |
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